Separation Process Principles was first published in 1998 to provide a comprehensive treatment of the major separation operations in the chemical industry. Both equilibrium-stage and mass-transfer models were covered. Included also were chapters on thermodynamic and mass-transfer theory for separation operations. In the second edition, published in 2006, the separation operations of ultrafiltration, microfiltration, leaching, crystallization, desublimation, evaporation, drying of solids, and simulated moving beds for adsorption were added. This third edition recognizes the growing interest of chemical engineers in the biochemical industry, and is renamed Separation Process Principles—Chemical and Biochemical Operations.
In 2009, the National Research Council (NRC), at the request of the National Institutes of Health (NIH), National Science Foundation (NSF), and the Department of Energy (DOE), released a report calling on the United States to launch a new multiagency, multiyear, multidisciplinary initiative to capitalize on the extraordinary advances being made in the biological fields that could significantly help solve world problems in the energy, environmental, and health areas. To help provide instruction in the important bioseparations area, we have added a third author, D. Keith Roper, who has extensive industrial and academic experience in this area.
New to This Edition
Bioseparations are corollaries to many chemical engineering separations. Accordingly, the material on bioseparations has been added as new sections or chapters as follows:
- Chapter 1: An introduction to bioseparations, including a description of a typical bioseparation process to illustrate its unique features.
- Chapter 2: Thermodynamic activity of biological species in aqueous solutions, including discussions of pH, ionization, ionic strength, buffers, biocolloids, hydrophobic interactions, and biomolecular reactions.
- Chapter 3: Molecular mass transfer in terms of driving forces in addition to concentration that are important in bioseparations, particularly for charged biological components. These driving forces are based on the Maxwell- Stefan equations.
- Chapter 8: Extraction of bioproducts, including solvent selection for organic-aqueous extraction, aqueous two- phase extraction, and bioextractions, particularly in Karr columns and Podbielniak centrifuges.
- Chapter 14: Microfiltration is now included in Section 3 on transport, while ultrafiltration is covered in a new section on membranes in bioprocessing.
- Chapter 15: A revision of previous Sections 15.3 and 15.4 into three sections, with emphasis in new Sections 15.3 and 15.6 on bioseparations involving adsorption and chromatography. A new section on electrophoresis for separating charged particles such as nucleic acids and proteins is added.
- Chapter 17: Bioproduct crystallization.
- Chapter 18: Drying of bioproducts.
- Chapter 19: Mechanical Phase Separations. Because of the importance of phase separations in chemical and biochemical processes, we have also added this new chapter on mechanical phase separations covering settling, filtration, and centrifugation, including mechanical separations in biotechnology and cell lysis.
Other features new to this edition are:
- Study questions at the end of each chapter to help the reader determine if important points of the chapter are understood.
- Boxes around important fundamental equations.
- Shading of examples so they can be easily found.
- Answers to selected exercises at the back of the book.
- Increased clarity of exposition: This third edition has been completely rewritten to enhance clarity. Sixty pages were eliminated from the second edition to make room for biomaterial and updates.
More examples, exercises, and references: The second edition contained 214 examples, 649 homework exercises, and 839 references. This third edition contains 272 examples, 719 homework exercises, and more than 1,100 references.
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