The Editors are pleased to present the 20th edition of Harrison’s Principles of Internal Medicine. This 20th edition is a true landmark in medicine, spanning 68 years and multiple generations of trainees and practicing clinicians. While medicine and medical education have evolved, readers will appreciate how this classic textbook has retained enduring features that have distinguished it among medical texts—a sharp focus on the clinical presentation of disease, expert in-depth summaries of pathophysiology and treatment, and highlights of emerging frontiers of science and medicine. Indeed, Harrison’s retains its conviction that, in the profession of medicine, we are all perpetual students and lifelong learning is our common goal.
Harrison’s is intended for learners throughout their careers. For students, Part 1, Chapter 1 begins with an overview of “The Practice of Medicine.” In this introductory chapter, the editors continue the tradition of orienting clinicians to the science and the art of medicine, emphasizing the values of our profession while incorporating new advances in technology, science, and clinical care. Part 2, “Cardinal Manifestations and Presentation of Diseases” is a signature feature of Harrison’s. These chapters eloquently describe how patients present with common clinical conditions, such as headache, fever, cough, palpitations, or anemia, and provide an overview of typical symptoms, physical findings, and differential diagnosis. Mastery of these topics prepares students for subsequent chapters on specific diseases they will encounter in courses on pathophysiology and in clinical clerkships. For residents and fellows caring for patients and preparing for board exams, Harrison’s remains a definitive source of trusted content written by internationally renowned experts. Trainees will be reassured by the depth of content, comprehensive tables, and illuminating figures and clinical algorithms. Many exam questions are based on key testing points derived from Harrison’s chapters. A useful companion book, Harrison’s Self-Assessment and Board Review, includes over 1000 questions, offers comprehensive explanations of the correct answer, and provides links to the relevant chapter in the textbook. Practicing clinicians must keep up with an ever-changing knowledge base and clinical guidelines as part of lifelong learning. Clinicians can trust that chapters are updated extensively with each edition of Harrison’s. The text is an excellent point-of- care reference for clinical questions, differential diagnosis, and patient management. In addition to the expanded and detailed Treatment sections, Harrison’s continues its tradition of including “Approach to the Patient” sections, which provide an expert’s overview of the practical management of common but often complex clinical conditions.
This edition has been modified extensively in its format as well as its content. We have reincorporated chapters that in previous editions were available only online. The 20th edition marks the return of Harrison’s “Further Reading” citations at the end of each chapter, providing references carefully selected by our contributors. The authors and editors have rigorously curated and synthesized the vast amount of information that comprises general internal medicine—and each of the major specialties—into a highly readable and informative two- volume book. Readers will appreciate the concise writing style and consistency of format that have always characterized Harrison’s. This book has a sharp focus on essential information with a goal of providing clear and definitive answers to clinical questions.
In addition to the printed book, Harrison’s is available on multiple digital platforms, including eBook and app versions, and via an online subscription available through McGraw-Hill’s popular Access Medicine (www.accessmedicine.com) collection. The digital editions feature an array of supplementary videos, databases, and photographic atlases as well as new literature updates, tutorials, animations, and audio discussions covering key topics in medicine. Harrison’s Manual of Medicine is a condensed pocket version of clinical essentials derived from the more comprehensive Harrison’s Principles of Internal Medicine. The Manual is also available as an eBook and an app and via Access Medicine. Together, these platforms form a potent Harrison’s collection of reference, test prep, and point-of-care online content.
Part 1. The Profession of Medicine
Part 2. Cardinal Manifestations and Presentation of Diseases
Part 3. Pharmacology
Part 4. Oncology and Hematology
Part 5. Infectious Diseases
Part 6. Disorders of the Cardiovascular System
Part 7. Disorders of the Respiratory System
Part 8. Critical Care Medicine
Part 9. Disorders of the Kidney and Urinary Tract
Part 10. Disorders of the Gastrointestinal System
Part 11. Immune-Mediated, Inflammatory, and Rheumatologic Disorders
Part 12. Endocrinology and Metabolism
Part 13. Neurologic Disorders
Part 14. Poisoning, Drug Overdose, and Envenomation
Part 15. Disorders Associated with Environmental Exposures
Part 16. Genes, the Environment, and Disease
Part 17. Global Medicine
Part 18. Aging
Part 19. Consultative Medicine
Part 20. Frontiers
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